At its inception in 1997, Otsuka was an affiliated company of Otsuka Pharmaceutical Co., Ltd. Japan, which began its journey in Indonesia under the name of PT Kapal Indah Otsuka. The company was formed from a joint investment between Otsuka Pharmaceutical Japan and PT Kapal Api with Pocari Sweat as its first product. Then in 1999, PT Kapal Indah Otsuka changed its name to PT Amerta Indah Otsuka.

As the company expanded, in 2004 PT Amerta Indah Otsuka opened its first factory located in Sukabumi, West Java following the next 6 years the Pocari Sweat factory in Kejayan, Pasuruan, East Java was established. With its success in marketing products, until now the products produced have been distributed throughout Indonesia. PT Amerta Indah Otsuka intensively distributes both directly through official branch offices and distributors spread throughout Indonesia and Southeast Asia.

Along with the company's progress, Otsuka is committed to continuously improving quality by implementing the ISO 9001: 2008 Quality Management System, the ISO 22000: 2005 Food Safety System, and the ISO 14001: 2004 Environmental Management System.